کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
239015 | 465789 | 2008 | 6 صفحه PDF | دانلود رایگان |
The aim of this study was to characterize lansoprazole (LSP) /PVP solid dispersion prepared by a fluid-bed coating technique. In vitro dissolution test in pH 7.4 phosphate buffer indicated that the dissolution rate was dramatically enhanced even at an LSP/PVP ratio of 1/1.75 or with more PVP. DSC and powder X-ray diffractometry proved the absence of crystallinity in LSP/PVP solid dispersion at a ratio of 1/2 or with more PVP. However, at an LSP/PVP ratio of 1/1, the LSP melting and decomposition peaks could be observed by DSC indicating presence of LSP crystalline in LSP/PVP solid dispersion. The FTIR spectrometry indicated formation of hydrogen bond between LSP and PVP.
DSC and powder X-ray diffractometry analysis indicated that lansoprazole crystalline has been inhibited in the PVP solid dispersion pellets prepared by a fluid-bed coating technique. FTIR results showed formation of hydrogen bonds between lansoprazole and PVP.Figure optionsDownload as PowerPoint slide
Journal: Powder Technology - Volume 182, Issue 3, 10 March 2008, Pages 480–485