کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
239628 | 466183 | 2015 | 8 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Synthesis and Characterization of Gadolinium Diethylenetriamine Pentaacetate-Folate
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موضوعات مرتبط
مهندسی و علوم پایه
مهندسی شیمی
مهندسی شیمی (عمومی)
پیش نمایش صفحه اول مقاله
![عکس صفحه اول مقاله: Synthesis and Characterization of Gadolinium Diethylenetriamine Pentaacetate-Folate Synthesis and Characterization of Gadolinium Diethylenetriamine Pentaacetate-Folate](/preview/png/239628.png)
چکیده انگلیسی
In our preliminary radiopharmaceutical study, 153Gd-DTPA-Folate has been successfully prepared, and tested for its bio-distribution. This continuing study is aimed at synthesizing and characterizing Gd-DTPA-Folate. The synthesis was started with the preparation of a derivative of folic acid, EDA-Folate, which was subsequently reacted with DTPA-Dianhydride to form DTPA-Folate. Finally, DTPA-Folate was reacted with Gd3+ to result in Gd-DTPA-Folate, on a 0.1-10 gram scale, with a yield of 97.2%. Experimental data collected from characterization of purified synthetic products using ultraviolet, infrared, and mass spectroscopy, indicated the formation of Gd-O and Gd-N bonds leading to the formation of Gd-DTPA-Folate molecule.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Procedia Chemistry - Volume 17, 2015, Pages 139-146
Journal: Procedia Chemistry - Volume 17, 2015, Pages 139-146