کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
239735 466199 2009 4 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Influence of statistical variations in cell distribution on the proliferation kinetics of Madin-Darby canine kidney cells on quartz crystal resonator
موضوعات مرتبط
مهندسی و علوم پایه مهندسی شیمی مهندسی شیمی (عمومی)
پیش نمایش صفحه اول مقاله
Influence of statistical variations in cell distribution on the proliferation kinetics of Madin-Darby canine kidney cells on quartz crystal resonator
چکیده انگلیسی

The influence of statistical variations in cell distribution on the proliferation of Madin-Darby canine kidney (MDCK-II) cells was analyzed. MDCK-II cells were cultivated in parallel on 4 quartz crystal resonators in a bioreactor chip. Results of proliferation experiments with different initial grade of confluence were compared. Light microscope pictures of the sensor surface and impedance spectra were continuously acquired. CFD simulation results of the bioreactor chip were employed to verify experimental conditions. Results show that especially at low confluency dissimilar development of non-confluent MDCK-II cell layers and resulting changes in acoustic load depend significantly on initial cell distribution.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Procedia Chemistry - Volume 1, Issue 1, September 2009, Pages 373-376