کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
239767 | 466228 | 2012 | 8 صفحه PDF | دانلود رایگان |
![عکس صفحه اول مقاله: Voltammetric DNA Biosensor Based on a Microcrystalline Natural Graphite–Polystyrene Composite Transducer Voltammetric DNA Biosensor Based on a Microcrystalline Natural Graphite–Polystyrene Composite Transducer](/preview/png/239767.png)
New voltammetric DNA biosensor based on a microcrystalline natural graphite–polystyrene composite film in the role of a transducer was used for the investigation of the interaction between model carcinogenic substance (2-aminofluorene; one of the most extensively studied examples of the aromatic amine class of carcinogens) and calf thymus double-stranded DNA (dsDNA). The layer of dsDNA immobilized at the electrode surface was utilized as a biocomponent responsive interface. The biosensor was characterized regarding the detection of DNA damage (induced by direct interaction with 2-aminofluorene) using square wave voltammetric responses of the guanine and adenine moieties and cyclic voltammetric responses of the anionic redox indicator [Fe(CN)6]4–/3– present in the solution.
Journal: Procedia Chemistry - Volume 6, 2012, Pages 52-59