کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
239971 | 466236 | 2016 | 9 صفحه PDF | دانلود رایگان |
![عکس صفحه اول مقاله: Immunogenicity and Specificity of Anti recombinant Protein Fim-C-Salmonella typhimurium Antibody as a Model to Develop Typhoid Vaccine Immunogenicity and Specificity of Anti recombinant Protein Fim-C-Salmonella typhimurium Antibody as a Model to Develop Typhoid Vaccine](/preview/png/239971.png)
Salmonella typhimurium, that cause typhoid fever in mice was used as a model to study typhoid fever in humans. This study is aimed to determine the immunogenicity of recombinant protein of Fim-C-S. typhimurium and specificity of antibody anti-recombinant protein of Fim-C-S. typhimurium in ddY mice. The immunogenicity studies by ELISA indicated that recombinant protein of Fim-C-S. typhimurium evokes strong immune response in ddY mice, particularly in experiment group. The specificity evaluated by Western Immunobloting technique indicated that the antibody anti-recombinant protein of Fim-C-S. typhimurium can detect the 31 kDa of recombinant protein of Fim-C-S. typhimurium as an antigen. This data reported that recombinant protein of Fim-C-S. typhimurium is immunogenic and the antibody anti-recombinant protein of Fim-C-S. typhimurium is specific. The results of this study can be used as a model to develop recombinant vaccine candidate against typhoid.
Journal: Procedia Chemistry - Volume 18, 2016, Pages 237-245