Iodination Method of Quercetin for Synthesis of Anticancer Labelled Compound

Quercetin is a bioflavonoid that has high potential as a candidate of anticancer. The in-vivo study of radicals detection methods in the body that causing cancer is limited. Therefore, the radiolabeled of an antioxidant compound to detect the radicals noninvasively are very useful. This research is conducted as a preliminary study for synthesis of anticancer therapeutic agent labelling compound using iodinated quercetin. The iodination of quercetin was conducted with oxidation of iodine using chloramine-T method. The result showed that the reaction of equimolar KI, Quercetin and chloramine-T, gave the product of sodium,-5’,6,8-triiodoquercetin. This method could be suitable to be used in the labelling of quercetin, using beta and gamma emitter radioactive of iodine-131 for anticancer therapeutic agent.