Optimization of Ketoprofen-loaded Chitosan Nanoparticle Ultrasonication Process

Ketoprofen-loaded chitosan was made by modifying poloxamer 188 and also varying time and amplitude of ultrasonication condition. Preliminary tests were carried out by optimizing ultrasonication condition including amplitude and sonication time. Nanoparticles characterization was carried out by using PSA, SEM, FTIR, and XRD. Optimum condition of sonication process was obtained when amplitude percentage and time used were 40% and 60 minutes, respectively. Three test formulas give nanoparticle percentage more than 95% with an average particle diameter below 400 nm.