Hepatoprotective Effects of Acalypha Indica and Centella Asiatica in Rat's Liver Against Hypoxia

Liver diseases are one of the major health problems worldwide and often difficult to treat. Hypoxia condition is one of its pathogenesis. This study was aimed to prove the hepatoprotective effects of the combination of Acalypha indica (AI) and Centella asiatica (CA) against hypoxia. Seven groups of Spraque-Dawley rats are used as follows: negative control without hypoxic condition, six other groups were put in hypoxic chamber and treated with water, AI, CA, two groups of AI-CA combination, and vitamin C, respectively. After 7 d of treatment, Malondialdehyde (MDA) levels were measured in plasma and liver. One of the AI-CA combination groups showed significant protective effect against hypoxia in liver (p < 0.001) but not in plasma.