Effects of Pigment-Protein Fraction from Nannocloropsis Oculata on TNFα and IL-6 which Act as an Anti-Inflammatory Against Viral Nervous Necrosis (VNN) Infection

The anti-inflammatory effect caused by VNN infection in the grouper fish using pigment-protein fraction of N.oculata has studied. Methods were to explore the pigment-protein fraction of N.oculata, in vivo test, and measurement of anti-inflammatory response using dot blott and immunohistochemistry technique. Results indicate that pigment-protein fraction of N. oculata was able to suppress grouper tissue inflammation when VNN infection was occurring. Inflammation sign was reduced by administration of pigment-protein fraction. This reaction was reinforced by raising of expression of TNFα and IL-6, which means that TNFα and IL-6 acts as an anti-inflammatory in fish tissue.