Sub-chronic Toxicity of Ficus Benjamina L. Leaves Ethanol Extract on the Liver Function of White Mice

Sub-chronic toxicity studies of ethanol extracts of Ficus benjamina L. leaves on liver function of white mice at doses of 200, 400 and 800 mg/kg body weight had been done. The weight ratio of liver, the serum alanine aminotransferase as well as aspartate aminotransferase activities were evaluated on day 61st after being treated daily for 60 days with the ethanol extract. The treatment was divided into four groups of white mice. The results showed that ethanol extract of Ficus benjamina L. leaves could increase the serum aspartate aminotransferase activity significantly (p<0.05) 60 days at doses of 400 and 800 mg/kg body weight and could increase the serum alanine aminotransferase activity significantly (p<0.05) after 60 days at doses of 800 mg/kg body weight. The weight ratio on liver of white mice were not significantly (p> 0.05) affected by this extract after 60 days application.