Influence of Storage Conditions on the Stability of Lactide

The objective following of the present study was to investigate the effect of different storage time and conditions on the stability of lactide. In this study the samples of lactide with different purities were stored under three various storage conditions and the compound integration was monitored for a period of 2 weeks. The storage conditions selected were (1) in the desiccator, (2) in the glove box under argon and (3) under ambient atmosphere. The purity of samples was performed on HPLC and Karl Fischer titration during all period of storage. It was shown that the initial purity of the lactide has a significant bearing on the lactide degradation.