کد مقاله کد نشریه سال انتشار مقاله انگلیسی ترجمه فارسی نسخه تمام متن
2430753 1553623 2016 4 صفحه PDF سفارش دهید دانلود رایگان
عنوان انگلیسی مقاله ISI
Identification, expression, and innate immune responses of two insulin-like peptide genes in the razor clam Sinonovacula constricta
ترجمه فارسی عنوان
شناسایی، بیان و پاسخ ایمنی ذاتی دو ژن پپتید شبه انسولین در constricta Sinonovacula صدف تیغ
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کلمات کلیدی
موضوعات مرتبط
علوم زیستی و بیوفناوری علوم کشاورزی و بیولوژیک علوم آبزیان
چکیده انگلیسی


• Two insulin-like peptide (ILP) genes were characterized from the razor clam Sinonovacula constricta.
• The ILP transcripts were widely expressed in adult tissues and the early developmental stages.
• The expression of the two ILP genes was significantly up-regulated after infection.

Insulin-like peptide (ILP) has emerged as a cell regulatory factor with multiple functions in vertebrates and invertebrates. In the present study, we identified and characterized two ILP genes, ILP1 and ILP2, in the razor clam Sinonovacula constricta. Both ILPs have a signal peptide and a mature domain consisting of six strictly conserved cysteines. The tertiary structure is divided into three main α-helices with a C-domain loop that separates helix 1 from helix 2. Both of ILPs were found to be regulated according to tissue type and developmental stage. After challenge with Vibrio anguillarum, Vibrio parahaemolyticus and Micrococcus lysodeikticus, the expression of two ILP genes was significantly up-regulated in the liver, hemocytes and mantle tissues, suggesting that the ILPs may play roles in the innate immunity in the razor clam Sinonovacula constricta.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Fish & Shellfish Immunology - Volume 51, April 2016, Pages 401–404
نویسندگان
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