|کد مقاله||کد نشریه||سال انتشار||مقاله انگلیسی||ترجمه فارسی||نسخه تمام متن|
|2456900||1554364||2015||8 صفحه PDF||سفارش دهید||دانلود رایگان|
این مقاله ISI می تواند منبع ارزشمندی برای تولید محتوا باشد.
- تولید محتوا برای سایت و وبلاگ
- تولید محتوا برای کتاب
- تولید محتوا برای نشریات و روزنامه ها
پایگاه «دانشیاری» آمادگی دارد با همکاری مجموعه «شهر محتوا» با استفاده از این مقاله علمی، برای شما به زبان فارسی، تولید محتوا نماید.
• Copy number variations (CNVs) have been thought as a very important source of genetic variability in human or animal genome. We first described a CNVs study by aCGH method in diverse Chinese sheep breeds.
• We identified a total of 245 CNVs and 1726 genes, which were located within 51 CNV Regions (CNVRs) in 5 different sheep breeds.
• By functional enrichment analysis, it indicates they are involved in the antigen processing, immune response, oxygen transporter, and heme binding.
• The results provide insights for the understanding of genetic variability in the sheep genome.
Copy number variations (CNVs) account for phenotypic variation and disease susceptibility in mammals. The characterization of these CNVs is important for understanding the molecular mechanisms and unraveling the complex genetic architecture of underlying diseases. In this study, we reported a genome-wide CNVs map in Chinese sheep breeds using a custom-designed Roche NimbleGen array comparative genome hybridization (aCGH) platform. We identified a total of 245 CNVs, which were located within 51 CNV Regions (CNVRs) in five different sheep breeds. Of these, 21 (41.18%) involved DNA losses, 23 (45.10%) involved DNA gains and 7 (13.73%) involved both. These CNVRs covered approximately 15.55 Mb of the sheep genome, and this coverage corresponded to 0.60% of the autosomal genome sequence. Moreover, we identified 1726 genes within or overlapping with these 51 CNVRs by functional enrichment analysis, which indicates that they are involved in antigen processing, the immune response, oxygen transport, and heme binding. The results elucidate the genetic variability in the sheep genome and offer genetic foundations for the construction of economically important phenotypes of sheep, such as sheep with high immunity and oxygen binding capability.
Journal: Small Ruminant Research - Volume 128, July 2015, Pages 19–26