کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
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2457895 | 1554414 | 2008 | 7 صفحه PDF | دانلود رایگان |
The purpose of this study was to investigate the comparative pharmacokinetics of difloxacin in male goat kids and lambs. Difloxacin was administered in a crossover as a single dose of 5 mg kg−1 b.wt. by the intravenous (i.v.) and intramuscular (i.m.) routes in kids and lamb. The concentrations of the drug in the plasma were measured using high-performance liquid chromatography (HPLC) with fluorescence detection. Following i.v. injection, the elimination half-life (t1/2β) in goat kids (3.57 ± 0.39 h) was higher than in lambs (2.63 ± 0.29 h). The apparent volume of distribution (Vdss) and the total body clearance (Cltot) in goat kids were 0.48 ± 0.03 l kg−1 and 0.12 ± 0.01 l kg−1 h−1, respectively. The corresponding values in lambs were 0.49 ± 0.04 l kg−1 and 0.11 ± 0.01 l kg−1 h−1, respectively. After i.m. administration, difloxacin reached a peak plasma concentration (Cmax) of 4.95 ± 0.53 and 4.25 ± 0.47 μg ml−1 at a post-injection time (Tmax) of 1.85 ± 0.23 and 1.31 ± 0.2 h in goat kids and lambs, respectively. The mean bioavailability (F) in both goat kids and lambs were 97.5 ± 20.61% and 97.1 ± 21.5%, respectively. The in vitro plasma protein binding % of difloxacin were 10.31 and 12.98 for goat kids and lambs, respectively. Using the surrogate marker Cmax/MIC and AUC24/MIC90, difloxacin could be effective by the i.m. route at 5 mg kg−1 against isolates with MIC ≤ 0.5 and 0.4 μg ml−1 for goat kids and lambs, respectively, after i.m. dosing.
Journal: Small Ruminant Research - Volume 78, Issues 1–3, August 2008, Pages 186–192