کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
2461649 1555045 2013 8 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Immunotherapy of mastitis
موضوعات مرتبط
علوم زیستی و بیوفناوری علوم کشاورزی و بیولوژیک علوم دامی و جانورشناسی
پیش نمایش صفحه اول مقاله
Immunotherapy of mastitis
چکیده انگلیسی

The aim of this study was to examine an alternative, immunologically based treatment for mastitis. A microbead carrying specific anti-mastitis bacteria antibodies and an enhancer of phagocytosis, termed Y-complex, was tested in two experiments. In experiment 1, 21 cows were challenged with Streptococcus dysgalactiae and treated with Y-complex, Cobactan LC® or saline. Y-complex cleared the bacteria by day 4 and by day 10 only one cow was positive and remained positive up to day 28. No bacteria were isolated from any of the seven cows treated with Cobactan LC after day 4; however, in two out of the seven cows, the bacteria were re-isolated on day 24. On day 28, cows treated with placebo had still not cleared the bacteria. Experiment 2 was a field study in which cows, naturally infected with Escherichia coli, S. dysgalactiae or coagulase-negative staphylococci (CNS), were treated with Y-complex (32 cows), sulfadiazine + trimethoprim or procaine penicillin + streptomycin (BA) (8 cows), or a non-steroidal anti-inflammatory drug (NSAID) (19 cows). Y-complex was as effective as antibiotics, and superior to NSAID, in eliminating bacteria. Milk quantity and quality following infection and treatment were similar for all treatments, but significantly less milk was discarded from cows treated with Y-complex as compared to antibiotics. Y-complex was proven to be safe and effective, and may serve as a new approach for the treatment of mastitis.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Veterinary Immunology and Immunopathology - Volume 153, Issues 3–4, 15 June 2013, Pages 209–216
نویسندگان
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