کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
2462157 1555066 2011 12 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Alterations of lymphocyte subpopulations in healthy dogs with aging and in dogs with cancer
موضوعات مرتبط
علوم زیستی و بیوفناوری علوم کشاورزی و بیولوژیک علوم دامی و جانورشناسی
پیش نمایش صفحه اول مقاله
Alterations of lymphocyte subpopulations in healthy dogs with aging and in dogs with cancer
چکیده انگلیسی

Changes in an individual's immune status are considered major contributing factors towards the morbidity of cancer and mortality of aging. To evaluate age-related changes in the immune status of dogs, the immunophenotypes (CD3, CD4, CD8 and CD21) of peripheral blood lymphocytes were measured in 160 healthy dogs aged from 1 to 17 years, and in 365 dogs with various tumors and at various stages. In healthy dogs, the absolute numbers of white blood cells, lymphocytes, and CD3+, CD4+ and CD21+ lymphocytes decreased significantly with age. The relative percentages of lymphocytes and CD4+ cells decreased significantly, while CD8+ cells increased significantly with age. The CD4:CD8 ratio showed a significant age-related decrease. In contrast, dogs with tumors possessed significantly lower absolute numbers and relative percentages of all lymphocyte phenotypes, while the CD4:CD8 ratio was significantly higher than in age-matched controls. The relative percentages of CD3+ and CD8+ lymphocytes were significantly lower in dogs with distant metastases compared with dogs without metastases, and the CD4:CD8 ratio increased with advanced stage. These observations illustrate the significant changes in immune status with age and the presence of marked immunological defects in a large-scale study of dogs with advanced tumors.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Veterinary Immunology and Immunopathology - Volume 142, Issues 3–4, 15 August 2011, Pages 189–200
نویسندگان
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