کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
2462307 1111402 2010 13 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Mastitis associated transcriptomic disruptions in cattle
موضوعات مرتبط
علوم زیستی و بیوفناوری علوم کشاورزی و بیولوژیک علوم دامی و جانورشناسی
پیش نمایش صفحه اول مقاله
Mastitis associated transcriptomic disruptions in cattle
چکیده انگلیسی

Mastitis is ranked as the top disease for dairy cattle based on traditional cost analysis. Greater than 100 organisms from a broad phylogenetic spectrum are able to cause bovine mastitis. Transcriptomic characterization facilitates our understanding of host–pathogen relations and provides mechanistic insight into host resistance to mastitis. In this review, we discuss effector mechanisms and transcriptomic changes within the mammary gland in response to experimental infections. We compare temporal, spatial and pathogen-specific local transcriptomic disruptions in the mammary gland as well as pathogen-induced systemic responses and transcriptional changes in distant organs. We attempt to explain why studies on transcriptomic changes during critical physiological periods and in response to non-mastitic pathogens may have important implications for mastitis studies. Future perspectives on revealing bidirectional molecular cross-talk between mastitis pathogens and host cells using cutting-edge genomic technologies are also discussed.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Veterinary Immunology and Immunopathology - Volume 138, Issue 4, 15 December 2010, Pages 267–279
نویسندگان
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