کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
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2463086 | 1555100 | 2008 | 4 صفحه PDF | دانلود رایگان |
![عکس صفحه اول مقاله: Feline immunodeficiency virus infection: A valuable model to study HIV-1 associated encephalitis Feline immunodeficiency virus infection: A valuable model to study HIV-1 associated encephalitis](/preview/png/2463086.png)
Feline immunodeficiency virus (FIV), like human immunodeficiency virus (HIV)-1, is a neurotropic lentivirus and is associated with neuropathology in natural and experimental infections. FIV enters the brain early following experimental infection, and virus has been proposed to enter the brain via the blood–brain barrier and blood–CSF barrier, within infected lymphocytes and monocytes/macrophages. However the entry of cell-free virus or the direct infection of brain endothelial cells and astrocytes of the blood–brain barrier may also contribute to CNS infection. This review explores the role played by the FIV model in the elucidation of mechanism of lentiviral entry to the brain and viral interactions with the CNS, particularly in relation to lymphotropic lentiviruses.
Journal: Veterinary Immunology and Immunopathology - Volume 123, Issues 1–2, 15 May 2008, Pages 134–137