کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
2463380 | 1555120 | 2006 | 14 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
DNA-protein immunization against the GapB and GapC proteins of a mastitis isolate of Staphylococcus aureus
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موضوعات مرتبط
علوم زیستی و بیوفناوری
علوم کشاورزی و بیولوژیک
علوم دامی و جانورشناسی
پیش نمایش صفحه اول مقاله
![عکس صفحه اول مقاله: DNA-protein immunization against the GapB and GapC proteins of a mastitis isolate of Staphylococcus aureus DNA-protein immunization against the GapB and GapC proteins of a mastitis isolate of Staphylococcus aureus](/preview/png/2463380.png)
چکیده انگلیسی
One of the most economically important diseases that affect the dairy industry is bovine mastitis caused by strains of S. aureus. The development of an effective vaccine has been hampered by the antigenic diversity of the bacterium. Immunization with plasmid DNAs, encoding S. aureus antigens either as single molecule or as chimeric products containing at least two antigens, has been proposed as a novel strategy to prevent this costly disease. We continued our studies on a chimeric protein composed of the surface-located GapB and GapC proteins of S. aureus and in this work we tested the effects of DNA vaccination with plasmids encoding the individual antigens as well as the GapC/B protein with or without a boost with the recombinant proteins. The results showed that DNA vaccination alone was unable to elicit a significant humoral response and barely able to elicit a detectable cell-mediated response to the recombinant antigens. These effects were overcome by boosting with the proteins indicating that these DNA vaccines alone were not sufficient to mount an immune response against the S. aureus GapB and GapC proteins.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Veterinary Immunology and Immunopathology - Volume 113, Issues 1â2, 15 September 2006, Pages 125-138
Journal: Veterinary Immunology and Immunopathology - Volume 113, Issues 1â2, 15 September 2006, Pages 125-138
نویسندگان
Oudessa Kerro-Dego, Tracy Prysliak, Andrew A. Potter, Jose Perez-Casal,