کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
2464783 1111808 2011 7 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Antinociceptive efficacy and plasma concentrations of transdermal buprenorphine in dogs
موضوعات مرتبط
علوم زیستی و بیوفناوری علوم کشاورزی و بیولوژیک علوم دامی و جانورشناسی
پیش نمایش صفحه اول مقاله
Antinociceptive efficacy and plasma concentrations of transdermal buprenorphine in dogs
چکیده انگلیسی

To assess the antinociceptive efficacy of transdermal (TD) buprenorphine (B) in dogs, a prospective, positive-controlled experimental study was performed in 10 healthy Beagles. In an open label crossover design, the dogs initially received intravenous B (IVB, 0.02 mg kg−1) as a positive control, followed by TDB (52.5 μg h−1) 4 months later. Blood was collected at regular intervals for determination of the plasma concentrations of B ([B]) and its metabolite norbuprenorphine. The antinociceptive efficacy was assessed using thermal and mechanical models of nociception. The peak concentration [B] was 1.54 ng mL−1 (±1.98) 60 h after TDB application, although three dogs had no measurable [B] after TDB. Maximum thermal threshold (TT) was 52.6 °C (±0.48) at 1 h after IVB administration and 51.63 °C (±1.01) 72 h after TDB application. The significant increase in TT indicated that effective antinociception was achieved beyond 36 h after the application of TDB, lasting until patch removal. There was hysteresis between [B] and the antinociceptive effect.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: The Veterinary Journal - Volume 187, Issue 3, March 2011, Pages 335–341
نویسندگان
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