The pharmacokinetic behaviour of marbofloxacin in Eurasian buzzards (Buteo buteo) after intraosseous administration

This study reports on the administration of a single dose of marbofloxacin (2 mg/kg) to five adult Eurasian buzzards (Buteo buteo) by the intraosseous (IO) route, which has been proposed as a rapid and efficient means for the parenteral delivery of antimicrobial drugs. The drug was rapidly absorbed. Peak marbofloxacin concentration (Cmax) in plasma and area under the concentration–time curve (AUC) of 1.92 ± 0.78 μg/mL and 8.53 ± 2.73 μg h/mL, respectively. The time marbofloxacin remained in the plasma after IO administration was relatively short (elimination half-life, t1/2β = 4.91 ± 0.65 h; mean residence time (MRT) = 5.38 ± 0.57 h). Single dose marbofloxacin gave values for Cmax/minimum inhibitory concentration (MIC) of 19.2 and an AUC/MIC value of 85.3 h after IO administration. The IO route appears to be practical and effective for the rapid delivery of marbofloxacin to buzzards.