کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
2478394 1113357 2008 6 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Rythmes biologiques et médicaments : une source de variabilité souvent négligée en pharmacologie
موضوعات مرتبط
علوم پزشکی و سلامت داروسازی، سم شناسی و علوم دارویی اکتشاف دارویی
پیش نمایش صفحه اول مقاله
Rythmes biologiques et médicaments : une source de variabilité souvent négligée en pharmacologie
چکیده انگلیسی
Several factors are known to induce changes in pharmacological response to drugs. The existence of biological rhythms is often neglected when assessing drug effects. Nevertheless, the best knowledge of biological rhythms have lead to medical applications, particularly chronopharmacology. Drug tolerance as well as drug effects are changing according to the hour of administration. These chronopharmacological phenomena may be explained by temporal changes in receptors drug binding or transductional effects, as well as pharmacokinetic variations in absorption, distribution, metabolism and elimination according to the moment of administration. Medical applications of such findings lead to choose the best moment of administration of the drug in order to improve the benefit/risk ratio.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Annales Pharmaceutiques Françaises - Volume 66, Issue 3, June 2008, Pages 185-190
نویسندگان
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