کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
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2478662 | 1556016 | 2013 | 7 صفحه PDF | دانلود رایگان |
BackgroundDiabetic nephropathy (DN) is one of the most serious complications of diabetes mellitus. Excessive activity of renin−angiotensin system plays a vital role in initiation and progression of DN. In addition, many studies have shown that inflammation plays a significant role in DN development.PurposeThis study was performed to evaluate the renoprotective effect of aliskiren (direct renin inhibitor) monotherapy and combination of aliskiren plus pentoxifylline (xanthine derivative) in hypertensive-diabetic type 2 patients with DN among patients in Gaza Strip.MethodsForty hypertensive-diabetic type 2 patients with microalbuminurea (20–200 μg/min or 30–300 mg/24 h) were selected from UNRWA and private clinics in Gaza Strip and divided into two groups. The first group (n = 20) was treated with aliskiren (150 mg/day), whereas the second group (n = 20) was treated with aliskiren−pentoxifylline combination (150, 400 mg/day). All patients were followed-up for nine months by measuring serum creatinine level and urinary albumin excretion (UAE) rate before and at 3, 6 and 9 months of treatment.ResultsThe results showed a significant reduction (P < 0.05) in UAE rate among patients who used aliskiren and aliskiren−pentoxifylline combination after 6 and 9 months of treatment, where the reduction in both groups was more pronounced at 9 months of treatment. Moreover, the results also showed a significant reduction (P < 0.05) in serum creatinine level after 6 and 9 months of aliskiren−pentoxifylline combination treatment, whereas the decrease became significant (P < 0.05) only after 9 months of aliskiren treatment.ConclusionAliskiren monotherapy and aliskiren−pentoxifylline combination improved kidney function among hypertensive-diabetic type 2 patients with DN, however, aliskiren−pentoxifylline combination had a better renoprotective effect.
Journal: Bulletin of Faculty of Pharmacy, Cairo University - Volume 51, Issue 2, December 2013, Pages 221–227