کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
2478684 1556015 2014 6 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Spectrophotometric method for the determination of amlodipine besylate in pure and dosage forms using 7,7,8,8-tetracyanoquinodimethane and tetracyanoethylene
ترجمه فارسی عنوان
روش اسپکتروفتومتری برای تعیین بیسیلات آملودیپین در فرم های خالص و دوز با استفاده از 7،7،8،8-تتراسین کانیدیمتان و تتراسانو اتیلن
موضوعات مرتبط
علوم پزشکی و سلامت داروسازی، سم شناسی و علوم دارویی اکتشاف دارویی
چکیده انگلیسی

Two simple, rapid and sensitive spectrophotometric methods for the determination of amlodipine besylate (ADB) in pure form and in pharmaceutical preparations have been developed. The methods are based on the charge transfer reactions between the drug as electron donor with 7,7,8,8-tetracyanoquinodimethane (TCNQ) and tetracyanoethylene (TCNE) as π-acceptors in order to the formation of charge transfer (CT) complexes. These reactions give colored products which have maximum absorption bands at 745 and 396 nm for TCNQ and TCNE, respectively. Beer’s law is obeyed in the concentration ranges 20–110 μg mL−1 and 5–35 μg mL−1 for ADB using TCNQ and TCNE reagents. The molar absorptivities are 2.73 × 103 and 6.43 × 103 L mol−1 cm and the Sandell (S) sensitivities are 0.14 μg cm−2 and 0.063 μg cm−2 using TCNQ and TCNE reagents, respectively, which indicate the high sensitivity of the proposed methods. The relative standard deviations (R.S.D.: 0.94 and 0.73) obtained using TCNQ and TCNE reagents, respectively, refer to the high accuracy and precision of the proposed method.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Bulletin of Faculty of Pharmacy, Cairo University - Volume 52, Issue 1, June 2014, Pages 109–114
نویسندگان
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