کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
2478715 1556018 2012 6 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Synthesis and evaluation of some new 1,2,4-triazolo(4,3-a)quinoxalin-4-5H-one derivatives as AMPA receptor antagonists
موضوعات مرتبط
علوم پزشکی و سلامت داروسازی، سم شناسی و علوم دارویی اکتشاف دارویی
پیش نمایش صفحه اول مقاله
Synthesis and evaluation of some new 1,2,4-triazolo(4,3-a)quinoxalin-4-5H-one derivatives as AMPA receptor antagonists
چکیده انگلیسی

This study involves the synthesis and anticonvulsant evaluation of 1-ethyl-3-hydrazinylquinoxalin-2-1H-one (8), and many other newly synthesized compounds (9–14). The structure of the synthesized compounds was confirmed by elemental analysis and spectral data (IR, 1H NMR and Mass). Docking studies were performed to all the synthesized compounds in order to rationalize the anticonvulsant activity of the proposed compounds in a qualitative way. There is a strong correlation between the results of molecular modeling and the anticonvulsant activity of the synthesized compounds. The highest fitting value was noticed for compounds 9 and 10 “which showed the highest anticonvulsant activity”.Figure optionsDownload as PowerPoint slide

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Bulletin of Faculty of Pharmacy, Cairo University - Volume 50, Issue 2, December 2012, Pages 141–146
نویسندگان
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