کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
2480356 1556182 2015 7 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Modelling of dissolving microneedles for transdermal drug delivery: Theoretical and experimental aspects
ترجمه فارسی عنوان
مدل سازی مایکروویو های حل کننده برای تحویل داروهای ترانسدورال: جنبه های تئوری و تجربی
کلمات کلیدی
آرایه میکروسکوپ حل کننده، حذف، گام صدا، مدل سوزن تک برآورد پارامتر
موضوعات مرتبط
علوم پزشکی و سلامت داروسازی، سم شناسی و علوم دارویی اکتشاف دارویی
چکیده انگلیسی

A mathematical model was developed to predict the amount of drug delivered into the skin via the dissolution of a microneedle (MN). This approach differs markedly from previous research which focused on similar phenomena but failed to include a biological membrane. Dimensionless governing equations were derived to help predict the needle height and fate of the active ingredient in the skin layer after application of the device. Simulation studies with fentanyl revealed that the drug concentration was proportional to its mass fraction in the MN. The effect of the pitch on skin permeation was mildly nonlinear. A larger amount of fentanyl was delivered from microneedle arrays with smaller pitch size. The dissolution process was independent of changes in the elimination rate constant. An optimization algorithm was applied to show how to recover this parameter from needle height – time data.

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ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: European Journal of Pharmaceutical Sciences - Volume 68, 20 February 2015, Pages 137–143
نویسندگان
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