کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
2480402 1556188 2014 7 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Generation of 1:1 Carbamazepine:Nicotinamide cocrystals by spray drying
ترجمه فارسی عنوان
تولید 1: 1 کاربامازپین: کیکرالیزهای نیکوتینامید با خشک شدن اسپری
کلمات کلیدی
کوکریستال، نمودار حلالیت فاز، نمودار فاز ترمینال، خشک کردن اسپری، مایع کمک سنگ زنی، کاربامازپین
موضوعات مرتبط
علوم پزشکی و سلامت داروسازی، سم شناسی و علوم دارویی اکتشاف دارویی
چکیده انگلیسی

The present study investigates the potential of spray drying as a technique for generation of pharmaceutical cocrystals. Carbamazepine–Nicotinamide cocrystal (CNC) was chosen as model cocrystal system for this study. Firstly, CNC was generated using liquid assisted grinding and used for generation of phase solubility diagram (PSD) and ternary phase diagram (TPD). Both PSD and TPD were carefully evaluated for phase behavior of CNC when equilibrated with solvent. The undersaturated region with respect to CNC, as depicted by TPD, was selected as target region to initiate cocrystallization experiments. Various points in this region, representative of different compositions of Carbamazepine, Nicotinamide and CNC, were selected and spray drying was carried out. The spray dried product was characterized for solid state properties and was compared with CNC generated by liquid assisted grinding. Spray drying successfully generated CNC of similar quality as those generated by liquid assisted grinding. Moreover, there was no significant impact of process variables on formation of CNC. Spray drying, owing to its simplicity and industrial scalability, can be a promising method for large scale cocrystal generation.

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ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: European Journal of Pharmaceutical Sciences - Volume 62, 1 October 2014, Pages 251–257
نویسندگان
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