کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
2480808 1556213 2012 8 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Anticancer activity, toxicity and pharmacokinetic profile of an indanone derivative
موضوعات مرتبط
علوم پزشکی و سلامت داروسازی، سم شناسی و علوم دارویی اکتشاف دارویی
پیش نمایش صفحه اول مقاله
Anticancer activity, toxicity and pharmacokinetic profile of an indanone derivative
چکیده انگلیسی

The present study describes anticancer effect of gallic acid based indanone derivative (1). Indanone 1 exhibited in vivo anticancer activity against Erhlich ascites carcinoma in Swiss albino mice by inhibiting tumor growth by 54.3% at 50 mg/kg b.wt. It showed antitubulin effect by inhibiting tubulin polymerase enzyme. In cell cycle analysis, it inhibited G2/M phase and induced apoptosis. It significantly suppressed VEGF-R1, VEGF-R2 and HIF-α in human breast cancer MCF-7 cells, thus exhibiting antiangiogenic activity. In acute oral toxicity, indanone 1 was well tolerated and was found to be non-toxic up to 1000 mg/kg b.wt. in Swiss albino mice. Pharmacokinetic studies in rabbits revealed rate of absorption, half life, volume of distribution with high plasma and blood clearance after i.v. administration. Indanone 1, is a safe and moderately active anticancer agent.

An antitubulin indanone (1) exhibits moderate in-vivo anticancer activity.Figure optionsDownload high-quality image (89 K)Download as PowerPoint slide

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: European Journal of Pharmaceutical Sciences - Volume 47, Issue 5, 18 December 2012, Pages 988–995
نویسندگان
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