کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
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2480840 | 1556206 | 2013 | 8 صفحه PDF | دانلود رایگان |
![عکس صفحه اول مقاله: Hyaluronan nanocapsules as a new vehicle for intracellular drug delivery Hyaluronan nanocapsules as a new vehicle for intracellular drug delivery](/preview/png/2480840.png)
Here we report the development of new drug nanocarriers – named hyaluronan nanocapsules – for the intracellular delivery of hydrophobic anticancer drugs. These nanocapsules are composed of a lipid core and a shell of hyaluronic acid (HA). Nanocapsules were produced by a modified solvent displacement technique, which allows the formation of the polymer shell around the oily core using a cationic surfactant as an interphase bridge. The resulting nanocapsules have a size of ∼200 nm, a negative zeta potential and a spherical shape. The model drug docetaxel could be efficiently encapsulated within their core. The in vitro cell culture studies (NCI-H460 cancer cell line) showed that the cytotoxicity of docetaxel could be significantly enhanced due to its encapsulation within the nanocapsules. Interestingly, the nanocapsules were stable during storage and they could also be transformed into a powder by freeze-drying. These novel nanostructures hold promise as intracellular drug delivery systems.
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Journal: European Journal of Pharmaceutical Sciences - Volume 49, Issue 4, 16 July 2013, Pages 483–490