کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
2481037 1556212 2013 9 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Development of solid lipid nanoparticles (SLNs) of lopinavir using hot self nano-emulsification (SNE) technique
موضوعات مرتبط
علوم پزشکی و سلامت داروسازی، سم شناسی و علوم دارویی اکتشاف دارویی
پیش نمایش صفحه اول مقاله
Development of solid lipid nanoparticles (SLNs) of lopinavir using hot self nano-emulsification (SNE) technique
چکیده انگلیسی

Solid lipid nanoparticles (SLNs) of poor orally bioavailable drug lopinavir were prepared using hot self nano-emulsification (SNE) technique. Hot isotropic mixture of stearic acid, poloxamer and polyethylene glycol was spontaneously self nano-emulsify in hot water and SLNs were formed with subsequent rapid cooling. Self nano-emulsification ability of stearic acid, poloxamer and polyethylene glycol mixture was assessed by ternary phase diagram study. Optimized SLNs were having particle size of 180.6 ± 2.32 nm (PDI = 0.133 ± 0.001), 91.5 ± 1.3% entrapment efficiency and zeta potential of −13.4 ± 0.56 mV. SLNs were evaluated by transmission electron microscopy (TEM) and atomic force microscopy (AFM) for morphological study. Further, Differential scanning calorimetry (DSC) and X-ray diffraction (XRD) of SLNs were also performed for checking solid state characterization. Higher oral bioavailability was found for lopinavir loaded SLNs in comparison to bulk lopinavir due to higher lymphatic drug transport (p < 0.05). Results indicate that SLNs of higher fatty acids can be successfully prepared by hot SNE technique.

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ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: European Journal of Pharmaceutical Sciences - Volume 48, Issues 1–2, 23 January 2013, Pages 231–239
نویسندگان
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