کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
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2481147 | 1556221 | 2012 | 9 صفحه PDF | دانلود رایگان |
![عکس صفحه اول مقاله: Neuroprotective effect of undecylenic acid extracted from Ricinus communis L. through inhibition of μ-calpain Neuroprotective effect of undecylenic acid extracted from Ricinus communis L. through inhibition of μ-calpain](/preview/png/2481147.png)
The key neuropathological features of Alzheimer’s disease are abnormal deposition of Aβ plaques and insoluble Aβ peptides in extracellular brain and intracellular neurofibril tangles induced by abnormal tau hyperphosphorylation. μ-Calpain is one of the factors that bridge these Aβ- and hyperphosphorylated tau-mediated pathological pathways. Undecylenic acid (UDA), a naturally occurring unsaturated fatty acid, was discovered as a μ-calpain inhibitor by screening a chemical library using a substrate specific μ-calpain assay method. UDA inhibited Aβ oligomerization and Aβ fibrillation and reversed Aβ-induced neuronal cell death. In addition, UDA scavenged ROS and reversed the levels of proapoptotic proteins induced by ROS in SH-SY5Y cells. UDA inhibited μ-calpain activity with better potency than the known peptide-like μ-calpain inhibitor, MDL28170, in SH-SY5Y and HEK293T cells transfected with the catalytic subunit of μ-calpain. These results suggest that UDA is a novel non-peptide-like μ-calpain inhibitor with good cell permeability and potent neuroprotective effect.
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Journal: European Journal of Pharmaceutical Sciences - Volume 46, Issues 1–2, 12 May 2012, Pages 17–25