کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
2481687 1556258 2009 8 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Triprotic acid–base microequilibria and pharmacokinetic sequelae of cetirizine
موضوعات مرتبط
علوم پزشکی و سلامت داروسازی، سم شناسی و علوم دارویی اکتشاف دارویی
پیش نمایش صفحه اول مقاله
Triprotic acid–base microequilibria and pharmacokinetic sequelae of cetirizine
چکیده انگلیسی

1H NMR-pH titrations of cetirizine, the widely used antihistamine and four related compounds were carried out and the related 11 macroscopic protonation constants were determined. The interactivity parameter between the two piperazine amine groups was obtained from two symmetric piperazine derivatives. Combining these two types of datasets, all the 12 microconstants and derived tautomeric constants of cetirizine were calculated. Upon this basis, the conflicting literature data of cetirizine microspeciation were clarified, and the pharmacokinetic absorption–distribution properties could be interpreted. The pH-dependent distribution of the microspecies is provided.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: European Journal of Pharmaceutical Sciences - Volume 37, Issues 3–4, 28 June 2009, Pages 321–328
نویسندگان
, , , , ,