کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
2482124 1556285 2007 6 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Nanoparticulate delivery system for insulin: Design, characterization and in vitro/in vivo bioactivity
کلمات کلیدی
موضوعات مرتبط
علوم پزشکی و سلامت داروسازی، سم شناسی و علوم دارویی اکتشاف دارویی
پیش نمایش صفحه اول مقاله
Nanoparticulate delivery system for insulin: Design, characterization and in vitro/in vivo bioactivity
چکیده انگلیسی

Insulin-loaded alginate–dextran nanospheres were prepared by nanoemulsion dispersion followed by triggered in situ gelation. Nanospheres were characterized for mean size and distribution by laser diffraction spectroscopy and for shape by transmission electron microscopy. Insulin encapsulation efficiency and in vitro release were determined by Bradford protein assay and bioactivity determined in vitro using a newly developed Western blot immunoassay and in vivo using Wistar diabetic rats. Nanospheres ranged from 267 nm to 2.76 μm in diameter and demonstrated a unimodal size distribution. Insulin encapsulation efficiency was 82.5%. Alginate–dextran particles suppressed insulin release in acidic media and promoted a sustained release at near neutral conditions. Nanoencapsulated insulin was bioactive, demonstrated through both in vivo and in vitro bioassays

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: European Journal of Pharmaceutical Sciences - Volume 30, Issue 5, April 2007, Pages 392–397
نویسندگان
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