کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
2482128 | 1556285 | 2007 | 8 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
N-Phthaloylchitosan-g-mPEG design for all-trans retinoic acid-loaded polymeric micelles
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کلمات کلیدی
موضوعات مرتبط
علوم پزشکی و سلامت
داروسازی، سم شناسی و علوم دارویی
اکتشاف دارویی
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چکیده انگلیسی
The amphiphilic grafted copolymer N-phthaloylchitosan-grafted poly(ethylene glycol) methyl ether (PLC-g-mPEG) was synthesized using chitosan with four different degrees of deacetylations (DD) (80, 85, 90 and 95%). All-trans retinoic acid (ATRA) was incorporated into PLC-g-mPEG by dialysis method in an attempt to optimize carriers for ATRA delivery. Morphological investigation by transmission electron microscopy (TEM) showed that the particles had round and uniform shapes. The particle sizes of ATRA incorporated into micelles were about 80-160Â nm depending on the initial drug-loaded and %DD of chitosan. Physicochemical properties of ATRA-loaded polymeric micelles were also investigated. It was found that %DD of chitosan, which corresponded to the N-phthaloyl groups in the inner core of the micelles, was a key factor in controlling the incorporation efficiency, stability of the drug-loaded micelles and drug release behavior. As the %DD increased, the incorporation efficiency and ATRA-loaded micelles stability increased. The sustained release profiles were also obtained at high %DD (90 and 95%). When compared to the unprotected ATRA, ATRA loaded in PLC-g-mPEG micelles was efficiently protected from photodegradation. This result suggested that loading of ATRA in micelles improved the chemical stability of ATRA.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: European Journal of Pharmaceutical Sciences - Volume 30, Issue 5, April 2007, Pages 424-431
Journal: European Journal of Pharmaceutical Sciences - Volume 30, Issue 5, April 2007, Pages 424-431
نویسندگان
Praneet Opanasopit, Tanasait Ngawhirunpat, Theerasak Rojanarata, Chantiga Choochottiros, Suwabun Chirachanchai,