کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
2483045 1114203 2016 7 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
From tablets to pharmaceutical nanotechnologies: Innovation in drug delivery strategies for the administration of antimalarial drugs
ترجمه فارسی عنوان
از قرص ها به فناوری های فناوری نانو: نوآوری در استراتژی های تحویل دارو برای اداره داروهای ضد مالاریا
موضوعات مرتبط
علوم پزشکی و سلامت داروسازی، سم شناسی و علوم دارویی اکتشاف دارویی
چکیده انگلیسی

Malaria pharmacotherapy has slowly progressed from empirical concoctions to present-age multidrug treatments. Malaria therapy complexity is due to the necessity of using multiple drugs to counter the insurgence of parasite resistance, while preventing recrudescence. The recent inclusion in malaria pharmacotherapy guidelines of drugs with suboptimal physicochemical characteristics, primarily artemisinin and its derivatives, urgently calls for the application of technological innovations in drug delivery systems for malaria treatment. New formulation approaches for the combination of two or more drugs in a single medicinal dosage form, could provide innovative medicinal products, improve therapeutic outcomes and enhance patient compliance. The present review focuses on recent technological innovations applied to the co-formulation of antimalarial drugs in drug delivery systems. Solid dosage forms, such as tablets capable of delivering combination of drugs with individual release rates (Dome Matrix® technology) and multiparticulate forms, such as dispersible soft agglomerates are discussed. Furthermore, the application of pharmaceutical nanotechnology to malaria pharmacotherapy is evoked and outlined.

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ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Journal of Drug Delivery Science and Technology - Volume 32, Part B, April 2016, Pages 167–173
نویسندگان
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