Particle size control and the interactions between drug and stabilizers in an amorphous nanosuspension system

Nanosuspension, especially the amorphous type of that, is an effective way to improve the dissolution properties of poorly water-soluble drugs. Amorphous nanosuspensions of resveratrol were prepared here by a precipitation method without homogenization or ultrasonication step attached. The interactions between drug and stabilizers were revealed by infrared (IR) spectra and differential scanning calorimetry (DSC) and interpreted with the assistance of modulation of their conformational dynamics. When nonionic polymer PVA was used as a stabilizer, PVP was found to be capable of controlling the size of secondary particles by inducing the aggregation and agglomeration of primary nanoparticles, which can be attributed to the formation of hydrogen bonds. This method could be applicable to controlling the size of nanoparticles or change their surface state in similar nanoparticle systems.

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