کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
2483461 1114225 2014 5 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
A Study of Tablets with a Co-Processed Dry Binder Containing Hypromellose and Α-Lactose Monohydrate
موضوعات مرتبط
علوم پزشکی و سلامت داروسازی، سم شناسی و علوم دارویی اکتشاف دارویی
پیش نمایش صفحه اول مقاله
A Study of Tablets with a Co-Processed Dry Binder Containing Hypromellose and Α-Lactose Monohydrate
چکیده انگلیسی

The paper examines the co-processed dry binder RetaLac from the aspect of its compressibility and dissolution of the active ingredient from tablets. RetaLac contains α-lactose monohydrate and hypromellose in the identical proportion. The same parameters are tested in the corresponding physical mixtures of Flowlac100 and various types of hypromellose (Metolose 100SR, Metolose 4000SR, Metolose 100000SR) and compared with the substance RetaLac. Compressibility is evaluated by means of the energy profile of compression and tensile strength of tablets. The values of the total energy of compression and plasticity were higher in the substance RetaLac than in the physical mixtures of lactose and various types of hypromellose; tablet strength, on the contrary, was lower. Dissolution profile of the active ingredient from tablets with RetaLac corresponded to the dissolution profile of tablets from a physical mixture of Flowlac 100 and Metolose 4000SR.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Journal of Drug Delivery Science and Technology - Volume 24, Issue 1, 2014, Pages 100-104