کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
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2483601 | 1114236 | 2011 | 7 صفحه PDF | دانلود رایگان |
Hydrogels are water-swollen, cross-linked polymeric structures. The objective of this study was to synthesize a new pH-sensitive copolymer, which shows no water uptake at lower pH values but a maximum water uptake at higher pH values. Methyl methacrylate-co-itaconic acid [P(MMA/ IA)] hydrogels cross-linked with methylene bis-acrylamide were synthesized. To determine the effect of monomeric composition, copolymers were prepared with different proportions of methyl methacrylate and itaconic acid i.e. 100:0, 90:10, 85:15, 80:20 and 75:25 keeping the degree of cross-linking constant i.e. 0.30 mol %. It was concluded from this study that the MMA/IA 75:25 (x = 0.3 mol %) polymer fulfilled our objective. It seems suitable for delivering the drug above pH 6.
Journal: Journal of Drug Delivery Science and Technology - Volume 21, Issue 3, 2011, Pages 249-255