کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
2483661 1114241 2010 7 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Effect of physical properties of orally disintegrating tablets on disintegration time as determined by a new apparatus
موضوعات مرتبط
علوم پزشکی و سلامت داروسازی، سم شناسی و علوم دارویی اکتشاف دارویی
پیش نمایش صفحه اول مقاله
Effect of physical properties of orally disintegrating tablets on disintegration time as determined by a new apparatus
چکیده انگلیسی

The purpose of this study was to evaluate the usefulness of a new disintegration testing apparatus, ODT-101, and to investigate the effects of the physical properties of orally disintegrating tablets (ODTs) on their disintegration time. We prepared ODTs of different weights and diameters at different tabletting pressures using an excipient Ludiflash. Disintegration times were measured by human sensory evaluation and using the ODT-101. The disintegration time measured by the ODT-101 was found to be in good agreement with that measured in the oral cavity. Disintegration time was found to be a function of porosity and weight, regardless of ODT shape, and to be an exponential function of the hardness of the ODT. In conclusion, ODT-101 testing is accurate enough to be a substitute for sensory evaluation and the hardness of the ODT is a good marker for disintegration time.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Journal of Drug Delivery Science and Technology - Volume 20, Issue 5, 2010, Pages 377-383