کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
2483792 | 1114252 | 2009 | 6 صفحه PDF | دانلود رایگان |
A powder solid dispersion system (SD) of indomethacin (IM) with crospovidone prepared by a twin-screw kneader or twin-screw extruder possessed good fluidity and was suitable for tablet formulation. Tablets of SD prepared by direct containing 25% IM. Aqueous film-coated SD tablets coated with Opadry OY7300 were obtained without recrystallizing during the coating process. The properties of SD powder, tablets and aqueous film-coated tablets were influenced by humidity during storage at 40 °C and 75% relative humidity (RH) under open conditions. IM in SD powder, tablets in all formulations and aqueous film-coated SD tablets maintained an amorphous state during storage at 40 °C and 75% RH in closed glass bottles for at least three months and solubility and tablet properties did not change during storage.
Journal: Journal of Drug Delivery Science and Technology - Volume 19, Issue 3, 2009, Pages 205-210