An anorganic bioceramic matrix for use as scaffold in bone regeneration: pharmaceutical development and preliminary biological evaluation

Regenerative medicine is an interdisciplinary field involving biology, medicine and engineering. It is focused on the repair, regeneration or replacement of cells, tissues or organs in order to restore their biological functionality to improve patients’ quality of life. The purpose of this work was to develop an anorganic bioceramic matrix obtained from natural and traceable bovine bones capable of acting as a scaffold and as a mineral reservoir for guided bone healing. The manufacturing process used went through several stages in order to assure the removal of all organic components. The products obtained were analyzed and a biological evaluation performed. An anorganic matrix derived from bovine bones with morphology similar to human cancellous bone was obtained. The biological evaluation has shown that the material was well integrated to the tissue with no signs of inflammation and the beginning of new bone formation. This biomaterial appears to be a promising candidate for future applications in tissue engineering and drug delivery as a scaffold with a porous structure.