کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
2488624 1556516 2013 6 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Design and in vitro/in vivo evaluation of extended release matrix tablets of nateglinide
موضوعات مرتبط
علوم پزشکی و سلامت داروسازی، سم شناسی و علوم دارویی اکتشاف دارویی
پیش نمایش صفحه اول مقاله
Design and in vitro/in vivo evaluation of extended release matrix tablets of nateglinide
چکیده انگلیسی
Of the seventeen formulated matrix tablets tested, only one formulation labelled HA-2 that contained 15% HPMC K4M demonstrated release profile we had aimed for. Further, swelling studies and scanning electron microscopic analysis confirmed the drug release mechanism of HA-2. The optimized formulation HA-2 was found to be stable at accelerated storage conditions for 3 months with respect to drug content and physical appearance. Mathematical analysis of the release kinetics of HA-2 indicated a coupling of diffusion and erosion mechanisms. In-vitro release studies and pharmacokinetic in vivo studies of HA-2 in rabbits confirmed the sustained drug release profile we had aimed for.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Journal of Young Pharmacists - Volume 5, Issue 4, December 2013, Pages 167-172
نویسندگان
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