Design and Microwave-assisted Synthesis of 1,3,4-Oxadiazole Derivatives for Analgesie and Anti-inflammatory Activity

1,3,4-Oxadizoles form a biologically important group of Compounds having activities like analgesic, anti- inflammatory, bactericidal, antifungal, anticonvulsant, psychotropic, plant growth regulating and mono amino oxidase inhibition. This research has focused on the incorporation ofthe oxadiazole moiety into isoniazid because oftheirversatile biological action, to get 2-aryl-5-(4-pyridyl)-1,3,4-oxadiazole to explore the possibilities of some altered biological action. 1,3,4-Oxadiazole derivatives were synthesized by microwave-assisted synthesis and screened for their analgesic, anti-inflammatory activities. The synthesized Compounds were characterized by Melting point, Thin layer chromatographylnfra red, Nuclear magnetic resonance spectroscopy, etc. Almost all the synthesized Compounds possessed good activity as compared to the Standard.