کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
2488830 | 1114982 | 2010 | 4 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Spasmolytic Activity of Fruits of Tamarindus indica L.
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موضوعات مرتبط
علوم پزشکی و سلامت
داروسازی، سم شناسی و علوم دارویی
اکتشاف دارویی
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چکیده انگلیسی
Objective: To study the possible effects of methanolic extract of fruits of Tamarindus indica on rabbit's jejunum preparations. Materials and Methods: The study was carried out on rabbit's jejunum preparations. Methanolic extract of fruits of T. indica was applied in different doses. Potassium chloride (KCl 80 mM)-induced contractions were relaxed by the extract. For determination of possible mode of action of relaxing effects, calcium chloride curves were constructed in decalcified tissues using K+ normal and followed by K+ rich solution. The curves were then compared with verapamil. Results: Relaxant effects on KCl-induced contractions were prominent at a concentration of 5.0-10.0 mg/ml (P< 0.05). A right shift at a concentration of 3.0 mg/ml (EC50 ± SEM = 1.98 ± 0.03) and 10.0 mg/ml (EC50 ± SEM = 1.79 ± 0.05) versus control (EC50 ± SEM = 2.33 ± 0.0585 resembled the effects of verapamil on the calcium chloride curves. Conclusion: The results confirmed its possible mode of relaxing effects i.e. through calcium channel blockade.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Journal of Young Pharmacists - Volume 2, Issue 3, JulyâSeptember 2010, Pages 261-264
Journal: Journal of Young Pharmacists - Volume 2, Issue 3, JulyâSeptember 2010, Pages 261-264
نویسندگان
N. Ali, S.W.A. Shah,