کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
2488888 | 1114984 | 2010 | 7 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Development and Validation of a Specific Stability Indicating High Performance Liquid Chromatographic Method for Valsartan
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موضوعات مرتبط
علوم پزشکی و سلامت
داروسازی، سم شناسی و علوم دارویی
اکتشاف دارویی
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چکیده انگلیسی
A stability-indicating HPLC assay method has been developed and validated for valsartan in bulk drug and pharmaceutical dosage forms. An isocratic RP-HPLC was achieved on Waters 2695 using Symmetry C18 (250 mm à 4.6 mm à 5 μ) column with the mobile phase consisting of 0.02 mM sodium dihydrogen orffro-phosphate, pH adjusted to 2.5 using orffro-phosphoric acid (solvent A), and acetonitrile (solvent B) in the ratio of 58:42 %v/v. The stress testing of valsartan was carried out under acidic, alkaline, oxidative, thermal, and photolytic conditions. Valsartan was well resolved from its degradation products. The proposed method was validated as per ICH guidelines. The method was found to be suitable for the quality control of valsartan in bulk and pharmaceutical dosage forms as well as the stability-indicating studies.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Journal of Young Pharmacists - Volume 2, Issue 2, AprilâJune 2010, Pages 183-189
Journal: Journal of Young Pharmacists - Volume 2, Issue 2, AprilâJune 2010, Pages 183-189
نویسندگان
K.S. Rao, N. Jena, M.E.B. Rao,