کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
2489187 1115023 2013 6 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Does a “thiol shield” protect tumors from natural IgM antibody, and, if so, how can it be suppressed?
موضوعات مرتبط
علوم زیستی و بیوفناوری بیوشیمی، ژنتیک و زیست شناسی مولکولی زیست شناسی تکاملی
پیش نمایش صفحه اول مقاله
Does a “thiol shield” protect tumors from natural IgM antibody, and, if so, how can it be suppressed?
چکیده انگلیسی

Natural anti-tumor IgM antibodies are prevalent in the serum of cancer patients and normal subjects. Extensive research has been directed toward the ultimate goal of achieving a therapeutic effect from these antibodies either augmented by vaccination or by passive infusion. To date, the therapeutic effects have been limited. This thesis asserts that thiols within solid tumors reduce pentameric IgM to monomeric or other subunit form resulting in inactivation of its complement fixing and cross linking apoptosis inducing properties. A rationale for this normal physiological inactivation mechanism, possibly necessary for wound healing and pregnancy, is proposed along with therapeutic approaches, which would potentially suppress IgM inactivation.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Medical Hypotheses - Volume 80, Issue 4, April 2013, Pages 425–430
نویسندگان
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