کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
2490160 1115060 2010 4 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
A novel brain injury mechanism after intracerebral hemorrhage: The interaction between heme products and the immune system
موضوعات مرتبط
علوم زیستی و بیوفناوری بیوشیمی، ژنتیک و زیست شناسی مولکولی زیست شناسی تکاملی
پیش نمایش صفحه اول مقاله
A novel brain injury mechanism after intracerebral hemorrhage: The interaction between heme products and the immune system
چکیده انگلیسی

SummaryIn this paper we hypothesize a novel mechanism by which brain injury occurs after intracerebral hemorrhage. We propose the following mechanism: (1) heme that is derived from extravasated erythrocytes is degraded into bilirubin and bilirubin oxidation products (BOXes). (2) Bilirubin and BOXes activate microglia and astrocytes, which are cells with immune functions in the brain. This activation leads to release of cytokines and activation of leukocyte adhesion molecules on the luminal surface of cerebral endothelial cells. (3) Leukocytes then traffic into the brain. (4) Leukocytes, activated glial cells and cytokines contribute to injury processes. We present preliminary data in support of our hypothesis that BOXes activate glia.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Medical Hypotheses - Volume 74, Issue 1, January 2010, Pages 63–66
نویسندگان
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