A new method for inducing bone tissue regeneration: Negative pressure membrane technology

SummaryWith the advances of medical molecular biology in recent years, our understanding of the process of fracture healing has deepened and the development of new technologies for guided bone regeneration has emerged. Here, with the recent discoveries of membrane-based as well as negative pressure-induced tissue regeneration, we suggest an innovative method of bone regeneration using negative pressure membrane technology. Polymeric membrane materials are implanted around the fracture site using in vitro devices. The container of the membrane between the fracture ends can induce effective negative pressure in order to attain both membrane and negative pressure-induced bone regeneration. The key to this technology is the use of semi-permeable membranes, which prevent the collapse of membranous structures and the loss of a variety of bone marrow cells and larger proteins during the induction of negative pressure.