کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
2490293 1115064 2009 4 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
The X-chromosome instability phenotype in Alzheimer’s disease: A clinical sign of accelerating aging?
موضوعات مرتبط
علوم زیستی و بیوفناوری بیوشیمی، ژنتیک و زیست شناسی مولکولی زیست شناسی تکاملی
پیش نمایش صفحه اول مقاله
The X-chromosome instability phenotype in Alzheimer’s disease: A clinical sign of accelerating aging?
چکیده انگلیسی

SummaryPremature centromere division, or premature centromere separation (PCS), occurs when chromatid separation is dysfunctional, occurring earlier than usual during the interphase stage of mitosis. This phenomenon, seen in Robert’s syndrome and various cancers, has also been documented in peripheral as well as neuronal cells of Alzheimer’s disease (AD). In the latter instances, fluorescent in situ hybridization (FISH), applied to the centromere region of the X-chromosome in interphase nuclei of lymphocytes from peripheral blood in AD patients, demonstrated premature chromosomal separation before mitotic metaphase directly after completion of DNA replication in G2 phase of the cell cycle. Furthermore, and perhaps unexpectedly given the presumptive post-mitotic status of terminally differentiated neurons, neurons in AD patients also showed significantly increased levels of PCS of the X-chromosome. Taken together with other phenomena such as cell cycle re-activation and ectopic re-expression of cyclins and cyclin dependent proteins, we propose that AD is an oncogenic phenotype leading to accelarated aging of the affected brain.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Medical Hypotheses - Volume 73, Issue 6, December 2009, Pages 917–920
نویسندگان
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