کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
2491281 | 1115083 | 2008 | 4 صفحه PDF | دانلود رایگان |
![عکس صفحه اول مقاله: A novel hypothesis of atherosclerosis: EPCs-mediated repair-to-injury A novel hypothesis of atherosclerosis: EPCs-mediated repair-to-injury](/preview/png/2491281.png)
SummaryRecent findings demonstrate the vital role of endothelial progenitor cells in the homeostasis of the vessel wall and the development of atherosclerosis. Endothelial progenitor cells (EPCs) play important roles in repair-to-injury of arteries. Many evidences have shown Cardiovascular risk factors closely correlated with EPCs numbers and function. Levels of circulating EPCs represented a better predictor of endothelial function than conventional risk factors. Depletion of bone marrow and Cardiovascular risk factors are the two prerequisits of atherosclerosis. All conditions of manifest atherosclerotic disease are accompanied by reduced EPC numbers and migratory capacity. Therefore, based on response-to-injury hypothesis and these findings, we build up EPCs-mediated repair-to-injury hypothesis, which may have important therapeutic implications in the prevention and therapy of atherosclerosis. The use of EPCs for vascular repair may be important therapy strategies with a maximized benefit for the patient in the future.
Journal: Medical Hypotheses - Volume 70, Issue 4, 2008, Pages 838–841